A Comparative Pilot Study of Three Portable Oxygen Concentrators

A Comparative Pilot Study of the Efficacy of Three Portable Oxygen Concentrators during a 6-minute Walk Test in Patients with Chronic Lung Disease

Rationale: While use of portable oxygen concentrators (POC) is likely to increase, research is limited on the ability of POC’s to maintain oxygen saturation ≥ 90% during exercise.

Objective: To compare the efficacy of 3 POC’s, with the highest O2 capacity in maintaining exertional O2 saturations ≥ 90% in patients with Chronic Obstructive Pulmonary Disease (COPD) or Pulmonary Fibrosis (PF).

Methods: Patients who were O2 dependent and within 2 years post pulmonary rehabilitation were invited to participate.

Inclusion criteria
Medically stable
R/A exertional
Desaturation ≤ 85%

Exclusions criteria
Require .6 L/min of oxygen
Conditions limiting walking ability
Significant cognitive or memory deficit

Six minute walk tests (6_MWTs) were administered, monitoring pulse oximetry (Sp02) . A control 6-MWT was performed with the participants’ current 02 system and prescribed exercise flow rate. A cross over design was used. Participants randomly performed a 6-MWT with each of the 3 POCs at the max pulse dose setting and stopped if their SP02 was ≤ 85%. A self admin, questionnaire was completed after each walk.

Study POCS
Respironics EverGo (Philips Respironics Inc. Murrysville, PA)
DeVilbiss iGo (DeVilbiss Healthcare. Summerset, PA)
SeQual Eclipse 3 (SeQual Eclipse 3, Caire Inc. Ball Ground, GA)

No financial support was received from the manufactures/distributors.

Results: Ten participants (5 male, 5 female, average 67.1 +/- 7.6 years old.) were included (9 COPD, 1PF). On average, the Eclipse 3 resulted in the highest Sp02 at each time point and corresponded with increased total time and total distance walked. Significant differences in Sp02 excisted between the Eclipse 3 and all other POCs ( p <0.05).

Sp02 before and after 6-MWT

Questionnaire Responses

Conclusions: All POCs increased Sp02 during exertional walk but only the Eclipse 3 resulted in mean SPo2 ≥ 90%.

1. McCoy R Petty T, Gay P. Comparison of three portable oxygen concentrators on exercising patients [White Paper]. Respironics, April 2008
2. Nasilowski J, Przybylowski T, Zeilinkski, J, Chazan R. Comparing supplementary oxygen benefits from a portable oxygen concentrator and liquid oxygen portable device during a walk test in COPD patients on long-term oxygen therapy. Resp Med 2008; 102: 1021.
3. Strickland S L, Hogan M T, Hogan R g et al. A randomized multi-arm repeated - measure prospective study of several modalities of portable oxygen delivery during assessment of functional exercise capacity. Respir Care 2009; 54 (no 3): 344
4. Enright PL, Sherrill DL. Reference Equations for the Six Minute Walk in Healthy Adults. Am J Respir Crit Care Med 1998; 158: 1384-1987

Leave a Reply